منابع مشابه
Lipids in leaves: fatty acid β-oxidation affects lipid homeostasis.
DNA, RNA, and proteins get a lot of attention, but without lipids, a cell is just a soup. Cellular membranes have a remarkable variety of lipids, and different organelles have different lipid compositions that must be maintained despite changes caused by vesicular trafficking among organelles (reviewed in Holthuis and Menon, 2014). Lipids move via vesicular trafficking, direct membrane contact ...
متن کاملFatty Acid oxidation defects.
Fatty acid oxidation defects (FAODs) are a group of inborn errors of metabolism that carry a risk for morbidity and mortality. Successful management of these conditions involves early diagnosis, proper management of clinical situations that predisposes to metabolic crisis as well as adequate treatment of a metabolic crisis. The advent of tandem mass spectrometry based newborn screening has redu...
متن کاملFatty acid oxidation
Fatty acids are the preferred oxidative substrates of the heart, skeletal muscles, kidney cortex and liver in adult mammals. They are supplied to these tissues either as nonesterified fatty acids (NEFAI, or as triglycerides after hydrolysis by lipoprotein lipase. During fetal life, tissue capacity to oxidize NEFA is very low, even in species in which the placental transfer of NEFA and carnitine...
متن کاملFatty Acid Oxidation
The heart consumes vast amounts of energy, and cardiac energetic impairment is a characteristic feature of several inherited and acquired diseases of heart muscle. In the fasting state, the heart typically generates ≈70% of its energy from β-oxidation of fatty acids, 10% to 30% from oxidation of glucose, and the remainder from ketones, lactate, and amino acids. However, it is a metabolic omnivo...
متن کاملThe effects of ginsenoside Rb1 on fatty acid β-oxidation, mediated by AMPK, in the failing heart
Objective(s): This study intended to investigate the effects of Ginsenoside-Rbl (Gs-Rbl) on fatty acid β-oxidation (FAO) in rat failing heart and to identify potential mechanisms of Gs-Rbl improving heart failure (HF) by FAO pathway dependent on AMP-activated protein kinase (AMPK). Materials and Methods: Rats with chronic HF, induced by adriamycin (Adr), were randomly grouped into 7 groups. Gs-...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m409640200